Tirzepatide is a new injectable medication that is making waves in the treatment of type 2 diabetesand obesity. Approved by health authorities in India, including the U.S. FDA, it offers a powerful new tool for patients struggling to manage blood sugar and weight. Here’s what you need to know.
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What is Tirzepatide?
Tirzepatide is a once-weekly injection used to:
• Control blood sugar in adults with type 2 diabetes.
• Support weight loss in adults who are obese or overweight with related health issues.
• Recently, it’s also been approved to help manage obstructive sleep apnea in patients with obesity.
It is sold under brand names such as Mounjaro (for diabetes) and Zepbound (for weight management).
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How much weight will you loose with Tirzepatide?
The amount of weight you can lose with Tirzepatide varies from person to person, but clinical studies have shown impressive results:
Average Weight Loss (as seen in studies):
• For weight loss (Zepbound):
People lost up to 15% to 22% of their body weight over about 72 weeks, depending on the dose.
• For type 2 diabetes (Mounjaro):
People lost around 12% to 16% of their body weight over a year, along with better blood sugar control.
Example:
If someone weighs 100 kg, they could lose 15 to 22 kg over time with proper use, diet, and exercise.
Weight loss usually starts within the first few weeks, but full effects take several months. Regular follow-up and lifestyle changes greatly improve results.
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How Does Tirzepatide Work?
Tirzepatide works by mimicking two natural hormones: GLP-1 and GIP. These hormones help regulate:
• Insulin release (which lowers blood sugar),
• Appetite (helps you feel full),
• Digestion (slows stomach emptying, reducing hunger).
Because of this dual action, Tirzepatide not only controls blood sugar but also leads to significant weight loss in many patients.
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Benefits of Tirzepatide
• Improves blood sugar control
• Promotes weight loss (more than many older medications)
• Reduces appetite and food cravings
• May help reduce the risk of diabetes in people with prediabetes
• Now shown to improve symptoms of sleep apnea in obese patients
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How Is It Taken?
• Given once a week as a subcutaneous injection (under the skin)
• Can be injected into the abdomen, thigh, or upper arm
• Always rotate the injection site each week
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Possible Side Effects
Like all medications, Tirzepatide may cause side effects. Common ones include:
• Nausea
• Diarrhea or constipation
• Decreased appetite
• Stomach discomfort
Serious (but rare) side effects:
• Pancreatitis (inflammation of the pancreas)
• Thyroid tumors (seen in animal studies; human risk not confirmed)
• Severe allergic reactions
Important: If you notice a lump in your neck, hoarseness, or difficulty swallowing, contact your doctor right away.
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Who Should Avoid Tirzepatide?
• People with a personal or family history of medullary thyroid cancer
• Those with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
• Patients with a history of pancreatitis
Always inform your doctor of your full medical history before starting.
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Summary
Tirzepatide is a promising medication for people with type 2 diabetes, obesity, or obstructive sleep apnea. It can significantly improve health outcomes when combined with healthy eating and physical activity.
However, it’s not a “magic bullet.” Like any medication, it works best as part of a comprehensive treatment plan tailored by your doctor.
Talk to your doctor to see if Tirzepatide could be right for you.
Dr. Karuturi Subrahmanyam, MD, FRCP (London), FACP (USA)
Internal Medicine Specialist
Kify Hospital
Danavaipeta
Rajahmundry
Phone : 85000 23456
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